Prohormone sequences used as training sets and discovered from genome resources

UIUC Neuroproteomics >> Welcome to NeuroPred >> Prohormone sequences

	Documentation Introduction Input Output


	Sequences Overview Aplysia Apis Drosophila Insect Insulin-like Various Insect Mammalian (Amare) Cattle Human Mouse Rat Rhesus monkey Cattle (Genome) Pig Chicken Zebra Finch Tribolium castaneum

	NeuroPred versions Current Test 2009 2006 NAR

Prohormone sequences used as training sets and sequences discovered from genome resources

Sequence and cleavage information is provided in a suitable format to be used directly in the Neuropred application to verify model predictions. They are in a modified FASTA format with a title, the sequence and a corresponding binary indicator of cleavage (1) or non-cleavage (0) for each amino acid in the sequence. By default, the Neuropred application will use the SignalP information and ignore the first x amino acids in the predictions.

Please acknowledge The Neuroproteomics and Neurometabolomics Center on Cell-Cell Signaling and the appropriate modeling papers include NeuroPred, when using the NeuroPred and these sequences in any publications in any form that may result from the use of this information.

Details on the sequences are available from the following papers:

Mollusk Sequences

Aplysia - Hummon et al., J. Proteome Res. 2003, DOI: 10.1021/pr034046d; Prohormone References/Table

Insect Sequences

Apis - Hummon et al., Science 2006, DOI: 10.1126/science.1124128. The gene names were taken from the Official protein set 1 at BeeBase (http://genomes.arc.georgetown.edu/). These names are based on Version 2 of the honey bee genome and are subject to change.
Drosophila, Insulin-like, Various - Southey et. al., Bioinformatics 2008, DOI: 10.1093/bioinformatics/btn044
Tribolium castaneum (Red flour beetle) Amare and Sweedler Peptides 2007, DOI: 10.1016/j.peptides.2007.04.014

Mammalian sequences

Mammalian - Amare et al., J. Proteome Res, 2006, DOI: 10.1021/pr0504541; Prohormone References/Table
Cattle Human Mouse Rat - Tegge et al., Mammalian Genome 2008, DOI: 10.1007/s00335-007-9090-9
Rhesus Genome Southey et al., Frontiers in Neuroinformatics 2008 http://www.frontiersin.org/neuroinformatics/paper/10.3389/neuro.11/007.2008/; Supplementary material
Cattle Genome Southey et al., BMC Genomics 2009, DOI: 10.1186/1471-2164-10-228
Pig Genome Porter et al., BMC Genomics 2012, DOI: 10.1186/1471-2164-13-582

Avian sequences

Chicken Delfino et al., Neuropeptides 2009, DOI: 10.1016/j.npep.2009.11.002

Zebra Finch Xie et al., BMC Biology 2010, DOI: 10.1186/1741-7007-8-28

Aplysia Insulin-like Drosophila Various Insects Cattle Human Mouse Rat Rhesus CattleGenome Pig Chicken ZebraFinch Tribolium Top

Prohormone sequences used as training sets and sequences discovered from genome resources

Mollusk Sequences

Insect Sequences

Mammalian sequences

Avian sequences

Aplysia californica Sequences

Apis mellifera Sequences

Insulin-like Sequences

Drosophila melanogaster Sequences

Various Insect Sequences

Mammalian Sequences

Cattle Sequences

Human Sequences

Mouse Sequences

Rat Sequences

Rhesus Sequences

Cattle Genome Sequences

Pig Genome Sequences

Chicken Sequences

Zebra Finch Genome Sequences

Tribolium castaneum Predicted Sequences